Effects of a personalized multidimensional physical exercise program on motor and cognitive symptoms of Parkinson’s disease.


It is estimated that Parkinson’s disease affects 2% to 3% of the world population over 65 years of age, occurring more frequently in older age groups, so age is a risk factor, together with other genetic, environmental, and biological variables. Its clinical characterization includes symptoms such as bradykinesia, resting tremor, rigidity, and postural instability, these symptoms are the cornerstone for its clinical diagnosis. However, there is a range of possible wide-ranging symptomatic manifestations, ranging from neuropsychiatric symptoms such as anxiety and depression; autonomic symptoms such as excessive daytime sleepiness, erectile dysfunction and constipation; cognitive symptoms such as cognitive deficit, deficits in attention, visuospatial deficit, memory, among other cognitive domains, thus denoting a heterogenous disease that demands interdisciplinary care models in order to lead the results to a better prognosis.

In addition to pharmacological interventions, non-pharmacological interventions promise beneficial effects that, together with pharmacological treatments, can synergize the therapeutic results in PD, therefore clinical research of this type of treatments is positioning different treatments such as physiotherapy, cognitive stimulation, physical training, tai-chi, tango and yoga as part of the therapeutic arsenal aimed to the care of Parkinson’s Disease.

Although, the evidence from physiotherapy and physical training is increasing in the literature, from animal models research and clinical trials focused on this type of population, which show neuroprotective and restorative effects, as well as improvement in motor and cognitive functionality, even there are difficulties in establishing a methodological approach that provides greater clarity in the clinical outcomes and analyzes implemented in this line of research, for which it is necessary to redouble efforts and implement intervention models in exercise programs that estimate multiple dimensions according to clinical and academic evidence. Based on this, it is hypothesized that an intervention program of this nature can improve motor and cognitive functioning in its multiple domains, which is the purpose of this study.

Requirements for research protocol volunteering.

  • Patients over 18 years old.
  • With Parkinson´s Disease diagnosis by a specialized clinician.
    At least four years since diagnosis.
  • Optimal treatment.  
  • Proper follow of treatment schedules and treatment dosses .
  • Capability to follow indications and task for the research protocol.  
  • Capability for understanding and sign the written consent.

Patients can participate for research protocols freely or leave the volunteering if:

  • There is a disease or medical condition that puts health or functionality at risk
  • Personal wish to leave the volunteering.

*Patients who wish participate and appear to be good candidates for research protocols may ask to any PRISMA specialist for additional information and beginning the eligibility process.

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